Antinuclear Antibodies (ANA) ELISA (96 wells) Cat 10876

Anti-dsDNA Antibodies ELISA (96 wells) Cat 10874

 Antibodies to double-stranded DNA (dsDNA) are often detected in patients with SLE. The presence of anti-dsDNA antibodies is one of the criteria used by the American College of Rheumatology to classify SLE.

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Anti-SS-A (Ro) Antibodies ELISA (96 wells) Cat 10870

SS-A antibodies are found in patients with SLE, Rheumatoid Arthritis (RA) and Sjogren’s Syndrome. These antibodies have also been found in patients with Systemic Sclerosis and Neonatal Lupus Erythematosus.

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Anti-SS-B (La) Antibodies ELISA (96 wells) Cat 10871

SS-B antibodies are found in patients with SLE, RA and Sjogren’s Syndrome. These antibodies have also been found in patients with Systemic Sclerosis and Neonatal Lupus Erythematosus. Antibodies to SS-B rarely occur in the absence of anti-SS-A antibodies. The risk of nephritis is higher in patients with SS-A antibodies in the absence of SS-B antibodies.

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Anti-Sm Antibodies ELISA (96 wells) Cat 10868

Sm antibodies are highly specific markers for SLE and may be found in up to 30% of SLE patients. They are commonly associated with nephritis and in severe cases with central nervous system involvement.

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Anti-RNP Antibodies ELISA (96 wells) Cat 10869

RNP antibodies may be found in up to 50% of SLE patients and in up to 95% of patients with MCTD. High levels of antibodies to the Sm/RNP complex, in the absence of anti-Sm antibodies are typical of MCTD.

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Anti-Scl-70 Antibodies ELISA (96 wells) Cat 10872

Scl-70 antibodies have been clinically associated with Scleroderma (with a prevalence of up to 40%) and PSS (with a prevalence of 20-30%). They are rarely found in other rheumatic diseases.

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Anti-Jo-1 Antibodies ELISA (96 wells) Cat 10873

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Anti-Centromere Antibodies ELISA (96 wells) Cat 10884

These have been detected in between 49% and 96% of CREST syndrome patients, with particular association with Raynaud’s phenomenon. They have also been reported in a number of cases of primary biliary cirrhosis in association with scleroderma.

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Anti-Mitochondrial Antibodies ELISA (96 wells) Cat 10877

The detection of these antibodies is very useful for the diagnosis of hepatic disease, in particular, 95% of biopsy-proven cases of primary biliary cirrhosis (PBC).

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Anti-LKM-1 Antibodies ELISA (96 wells) Cat 10878

Anti-MPO (pANCA) Antibodies ELISA (96 wells) Cat 10886

Anti-Myeloperoxidase (MPO) antibodies occur in such conditions as vasculitis, glomerulonephritis, Churg-Strauss syndrome, polyarteritis nodosa and SLE. Target antigens such as human leukocyte esterase, cathepsin-G and lactoferrin have been associated with pANCA, but in up to 50% of pANCA positive sera, the target antigen(s) are unidentified.

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Anti-PR3 (cANCA) Antibodies ELISA (96 wells) Cat 10881

Anti-Proteinase III (PR3) antibodies are present in a spectrum of diseases varying from idiopathic pauci-immune necrotizing glomerulonephritis to extended Wegener's Granulomatosus (WG). cANCA is present in greater than 90% of patients with extended WG. Reported sensitivity of anti-PR3 antibodies in cANCA positive serum is between 70% and 100%.

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Anti-Thyroid Peroxidase Antibodies ELISA (96 well) Cat 10880

Thyroid peroxidase (TPO) is an organ-specific enzyme, which plays a central role in thyroid hormone synthesis. Antibodies to TPO are present in many patients with advanced thyroiditis.

Anti-Thyroglobulin Antibodies ELISA (96 well) Cat 10879

Thyroglobulin (Tg) is one of the major autoantigens related to chronic autoimmune thyroiditis. It is detected along with TPO in most cases of Graves disease and Hashimoto’s disease.

Anti-Polymer (APA) Anitbodies ELISA (96 well) Cat 11440

The APA ELISA is intended for use as an aid in the diagnosis of patients presenting with the symptoms and signs of fibromyalgia syndrome, as an aid in differentiating fibromyalgia patients from patients with other autoimmune diseases and as an aid in identifying a subgroup of fibromyalgia patients having a unique characteristic immune response.

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